B.S. Abdur Rahman University,
Seethakathi Estate,
Vandalur,
Chennai -600048.
Phone :+91-44-22751347,48,50,75

Faculty: Dr. NEESAR AHMED

Dr. NEESAR AHMED
Dr. NEESAR AHMED
Designation :       Assistant Professor (sr. Gr.)
Nature of Employment :       Regular
Qualification :       M.Sc,
Phone :       Ext :380(Office)
Email :       neesar.sls@bsauniv.ac.in

Teaching

Education
  • Ph.D. (NCCS, Pune University, India)
  • M.Sc. (Aligarh Muslim University, Aligarh, India)
  • B.Sc (Aligarh Muslim University, Aligarh, India)

Specialization:
  • Tumor immunology, Cancer Biology, Signal Transduction.

Professional Experience:
  • Postdoctoral Research Fellow at Wayne State University, USA (2011-2013)

Area Of Research Interest

Our group research is focused on inflammatory disorders in various human diseases and Immunotherapy. I am interested in investigating the mechanisms engaged by tumors to evade cancer immunosurveillance with special interest in the role and function of immunosuppressive cells. Our group is involved in studying the Ubiquitin mediated regulation of the inflammatory Tumor Microenvironment and Targeting E3 ligases involved in inflammation.

      

Immunosuppressive Tumor Microenvironment (Adil et al 2014, Oncobiology and target)

Specialization:

  •  Cell biology, Cell signaling, Immunology, tumor microenvironment, Stress response and Inflammation biology.Key Words: Cancer Immunology, Immuno editing, Immunosuppressive tumor microenvironment, the biology of caveolae mediated signaling, stress and stimulant in cancer cells, stress proteins, immuno-modulation by lectin.

Research

List of Publications:

  • Sub-Micellar Concentration of Sodium Dodecyl Sulphate Prevents Thermal Denaturation Induced Aggregation of Plant Lectin, Jacalin. V Lavanya, BA Kumar, S Jamal, MKA Khan, N Ahmed. The Protein Journal 36 (1), 17-27.
  • Sustained mitogenic effect on K562 human chronic myelogenousleukemia cells by dietary lectin, jacalin. Lavanya V, Neesar Ahmed, Md. KhurshidAlam, Shazia Jamal.Glycoconj. J
  • "Cancer Immunotherapy: Targeting Immunosuppressive Tumor Micronment”Mohamed Adil A.A, Lavanya V, Shazia Jamal, Neesar Ahmed*Oncobiology and Targets. School of Life Science, B S AbdurRahman University.Inpress.2014
  • Small molecule inhibitors as emerging cancer therapeutics.Lavanya V, Mohamed Adil A.A, Neesar Ahmed, Shazia Jamal. Integrative Cancer Science and Therapeutics 1 (3), 39-46
  • The E3 ligase Itch and deubiquitinaseCyld act together to regulate Tak1 and inflammationAhmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R,Venuprasad K.. Nature Immunolgy.2011 Nov 6;12(12):1176-83. doi:10.1038/ni.2157. PubMed PMID: 22057290; PubMed Central PMCID: PMC3219826.
  • Taxol and 10-deacetylbaccatinIII induce distinct changes in the dynamics ofcaveolae.Ahmed N, Dasari S, Srivastava SS, Sneh A, Ahmad A, Islam Khan M, KrishnasastryMV.FEBS Lett. 2008 Oct 29;582(25-26):3595-600. doi: 10.1016/j.febslet.2008.09.029. Epub 2008 Sep 24. PubMed PMID: 18817775.
  •  Modulationof PP2A activity by Jacalin: is it through caveolae and ER chaperones? Ahmed N,Pany S, Rahman A, Srivastava SS, Sneh A, Krishnasastry MV.GlycoconjJ. 2010 Oct;27(7-9):723-34. doi: 10.1007/s10719-009-9258-5. Epub 2009 Oct 13.PubMed PMID: 19823931.
  • Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalinin two human carcinoma cell lines.Sahasrabuddhe AA, Ahmed N, Krishnasastry MV. Cell Stress Chaperones. 2006Summer;11(2):135-47. PubMed PMID: 16817319; PubMed Central PMCID: PMC1484514.
  •  Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: a non-conventional hemolysin and a ribosomal RNA methyl transferase.Rahman A, Srivastava SS, Sneh A, Ahmed N,Krishnasastry MV. BMC Biochem. 2010 Sep 20;11:35. doi: 10.1186/1471-2091-11-35. PubMed PMID: 20854656; PMC2954847.
  •  Membrane boundmonomer of Staphylococcal alpha-hemolysin induces caspase activation and apoptotic cell death despite initiation of membrane repair pathway.Srivastava SS, Pany S, Sneh A, Ahmed N, Rahman A, Musti KV. PLoS One.2009 Jul 21;4(7):e6293. doi: 10.1371/journal.pone.0006293. PubMed PMID: 19621082; PubMed Central PMCID: PMC2708924.
  • Crystal structure of single chain recombinant jacalin showing highly dynamic posttranslational excission loop that reduce binding affinity. Sharma U, Ahmed N,Krishnasastry MV, Suresh CG. MMDB ID: 85986PDB ID: 3P8S

International Conferences:

  • “Ubiquitin mediated regulation of inflammation in wound repair.Neesar Ahmed. School of Life Sciences. B.S. AbdurRahman University, Vandalur, Chennai-­‐600048.In:Preceeding of 2nd international and 7th National Annual Conference of the society for Wound care and research.11th -­‐13th October2013. JIPMER Puducherry,INDIA.
  •  "Phosphorylation dependent regulation of Itch-Cyld ubiquitin editing complex Neesar Ahmed, MinghuiZeng, and K Venuprasad.Institute‐Wide Research Retreat, Karmanos Cancer Institute, Detroit US.Posterpresentation 2012.
  • "Phosphorylation dependent regulation of Itch-Cyld ubiquitin editing complex during inflammatory signaling". Neesar Ahmed, MinghuiZeng, and K Venuprasad.Oral and poster presentation.41st Autumn Immunology Conference, 2012, Chicago US.
  • "Phosphorylation dependent regulation of Itch-Cyld ubiquitin editing complex duringinflammatorysignaling". Neesar Ahmed, MinghuiZeng, and K Venuprasad.
  •  Frontiers of Tumor and Microenvironment Poster Session, Karmanos Cancer Institute, Detroit US.Poster presentation 2012

Research Scholar supervising

S. No

Name of research Scholar

Title of PhD Work

1

Adil Mohammed A A

Immunosuppresive cell within Tumor microenvironment

2

Anil B Kumar

Ubiquitin mediated regulation of the Inflammatory Tumor Microenviromnment in specialized lipid raft

3

Logesh R

Immunology of MBt within macrophage

Awards

Honors and Awards
  • Senior Research Fellowship (2006-2009) awarded by the University Grant Commission, India.
  • Junior Research Fellowship (2004-2006) awarded by the University Grant Commission, India.
  • Fellowship (2002-2004) awarded by Department of Biotechnology, Govt of India.

TOP